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Sciences Solutions


Chemistry of Vitaldose® EVA

VitalDose® EVA is easy to formulate with because it truly is a random copolymer of ethylene and vinyl acetate. The key properties for achieving the desired drug release profile are achieved through control of the vinyl acetate content (6% to 40%). Through this single variable, the polarity and crystallinity of the polymer can be tailored and controlled to meet desired specifications.

Our controlled release VitalDose® EVA copolymers meet the chemical and physical properties required for many drug formulations. VitalDose® EVA can be processed at low temperatures for sensitive biologics; furthermore, has broad solubility characteristics for small molecules. VitalDose® EVA may be processed with a variety of manufacturing methods and is compatible with additional excipients to address specific requirements.

Multiple grades of VitalDose® EVA can be combined into a single device to achieve a specific drug release profile. The below diagram illustrates a hypothetical design where: (1) VitalDose® EVA with 40% vinyl acetate serves as a drug matrix and (2) VitalDose®EVA with 18% vinyl acetate on the exterior of the implant serves as the rate control membrane. The result is a drug delivery system with high drug loading providing zero-order release characteristics as illustrated in the diagram.

zero order delivery

Ethylene Vinyl Acetate (EVA polymers are a copolymer of Ethylene and Vinyl Acetate)
How EVA polymers are made from Ethylene and Vinyl Acetate

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