Stay connected to our news and events via the Celanese social channel experience and see where we are improving the world through our people, products and processes.


Contact Us

Healthcare and Life
Sciences Solutions


Chemistry of Vitaldose® EVA

VitalDose® EVA is easy to formulate with because it truly is a random copolymer of ethylene and vinyl acetate. The key properties for achieving the desired drug release profile are achieved through control of the vinyl acetate content (6% to 40%). Through this single variable, the polarity and crystallinity of the polymer can be tailored and controlled to meet desired specifications.

Our controlled release VitalDose® EVA copolymers meet the chemical and physical properties required for many drug formulations. VitalDose® EVA can be processed at low temperatures for sensitive biologics; furthermore, has broad solubility characteristics for small molecules. VitalDose® EVA may be processed with a variety of manufacturing methods and is compatible with additional excipients to address specific requirements.

Multiple grades of VitalDose® EVA can be combined into a single device to achieve a specific drug release profile. The below diagram illustrates a hypothetical design where: (1) VitalDose® EVA with 40% vinyl acetate serves as a drug matrix and (2) VitalDose®EVA with 18% vinyl acetate on the exterior of the implant serves as the rate control membrane. The result is a drug delivery system with high drug loading providing zero-order release characteristics as illustrated in the diagram.

zero order delivery

Ethylene Vinyl Acetate (EVA polymers are a copolymer of Ethylene and Vinyl Acetate)
How EVA polymers are made from Ethylene and Vinyl Acetate

Let us help

Contact us for help with customization

This website uses 'cookies' to give you the best, most relevant experience. Using this website means you are Ok with this. You can change which cookies are set at any time - and find out more about them - by following this link.

Information on the processing of your personal data within the USA by Google and Marketo:
By clicking "Accept All", or selecting "Marketing" and/or "Analytical" and then clicking "Accept Selected", you also consent in accordance with Art. 49(1)(a) GDPR that your data may be processed in the USA. The USA is considered by the European Court of Justice to be a country with no adequate level of data protection according to EU standards. In particular, there is a risk that your data may be processed by US authorities for surveillance and investigation purposes, possibly without the opportunity for legal remedies. If you select “Necessary” and then click on "Accept Selected”, the transfer described above will not take place. You will find more detailed information in our privacy policy.